As Giants defensive coordinator Wink Martindale said of the Packers QB, 'It's like owning a python and saying, 'Don't worry about it, he won't bite.'" Full list of Mr. Irrelevants in NFL draft history: Is Brock Purdy already the best final pick? . The Colts' three losses have come to the same three teams that San Francisco has lost to -- Arizona, Los Angeles Rams and Seattle -- and Indianapolis lost those games by a combined 68 points. FPI prediction: NE, 85.7% (by an average of 14.7 points), Matchup must-reads: Meet Brady's most trusted teammate: His 1995 shoulder pads Redskins' January decision to maintain status quo looks bad in hindsight Patriots' offense searching for identity, as it did in 2018, 1 p.m. ET | CBS It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. Betting nugget: Chicago is 4-12 ATS as an underdog since the start of last season. Chalk home | NFL home | CFB home, Bold prediction: The Cardinals' passing game will finally lead them to a win. Patrick Mahomes has been as good against the Raiders as any opponent, with a 7-1 record, 22 touchdowns and just three interceptions. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. -- Katherine Terrell, Bold prediction: Ryan Neal will take over for Josh Jones in the starting lineup and spark Seattle's struggling defense with a game-changing takeaway. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. Jets 20, Browns 17 -- Rich Cimini, Old friend Josh McCown is healthy and completing 70 percent of his passes, and the Jets have won two in a row with the kind of run-pass balance that the Browns should study. -- Mike Wells. ET games. The first round of the 2023 NFL Draft certainly had its moments, as three quarterbacks went within the first four picks and each of the major conferences had a player selected for the first time . Matchup rating: 65.6 | Spread: NO -3 (46.5), What to watch for: Is this the week we see the training wheels come off for Teddy Bridgewater? NFL picks, predictions for Week 5 Los Angeles Rams (-1.5) at Seattle Seahawks Thursday, 8:20 p.m., FOX/NFL Network The NFC West grinder continues. This is a matchup of the worst passing offense in the NFL (Jets, 131 yards per game) vs. the worst passing defense (324 yards per game). See Week 5 rankings. Walder's pick: Eagles 23, Cardinals 20 Spread: GB -8.0 (41), What to watch for: This could be a nightmare matchup for the Packers' defense. Watson will continue to play well, but the Texans defense will have a tough time containing the speed Kansas City has on offense. Betting nugget: Last season, first-round quarterbacks making their first career starts went 0-5 ATS. The model also enters Week 5 of the 2021 season on an incredible 124-82 run on top-rated NFL picks that dates . This has the makings of another close loss. Stat to know: Texans edge rusher Whitney Mercilus now has four straight games with a sack, tied for the longest active streak in the NFL with Clay Matthews and Shaquil Barrett. Quarterback Jacoby Brissett has led the Colts to more than 30 points in a game only once in 19 starts, and that was 31 points in his second start back in Week 3 of the 2017 season. The Cardinals have allowed a league-high 20 sacks; the Bengals are right behind them at 19. Betting nugget: Bridgewater is 25-7 against the spread (ATS) in his career as a starting quarterback, the best mark by any QB with at least 15 starts in the Super Bowl era. Stat to know: Oakland's Darren Waller enters play with 33 receptions, tied for the most by a tight end through the first four games in NFL history (Antonio Gates, 2007). Reiss' pick: Patriots 30, Redskins 6 He is tied with Russell Wilson for the most in the NFL in that span. The team that gets the running game going will have a decisive advantage. The Jags likely won't have cornerback Jalen Ramsey, and the domino effect of his absence will be a major issue when McCaffrey lines up on the outside. However, Miami is vastly improved in that area, allowing just 3.1 yards per rush and 78 yards per game this season. What to know for fantasy: T.J. Hockenson had 24.2 fantasy points through three weeks before exploding for a career-best 39.9 points last week against the Seahawks. 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades. Cowboys D reaching elite levels of legendary Doomsday Defense? -- Eric Woodyard. Cimini's pick: Eagles 27, Jets 9 ET | CBS Sure, the Packers have found replacements for all three, but those were big-time players who performed in the clutch. Time/station: 8:20 PM EST, ESPN. The Pats are coming off a 16-point performance in which quarterback Tom Brady completed just 18 of 39 passes for 150 yards and an interception. 2022 NFL Expert Picks | ESPN -- John Keim, Bold prediction: Titans quarterback Ryan Tannehill will finish with 300 passing yards in a win over the Commanders. The Week 5 NFL slate is stacked with great matchups. And the Chargers have allowed 5.4 yards per rush, the second worst in the NFL. FPI prediction: HOU, 64.0% (by an average of 5.0 points), Matchup must-reads: How Watson's 'NFL experience' began as ball boy for the Falcons TE Hooper could be the next Falcon to cash in Quinn not worried about job, his staff, 1 p.m. 2023 NFL Draft props, picks: Michael Mayer Under 23.5 ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. NFL Expert Picks - Super Bowl Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 10 Week 11 Week 12 Week 13 Week 14 Week 15 Week 16 Week 17 Week 18 Wild Card Divisional Round . Read more. Read more. There will be 259 total selections over a three-day period . NFL football pool, pick'em, office pool, confidence picks: Select the Finally, Seth Walder and Eric Moody give us final score picks for every game. Victor Cruz contends that Gardner Minshew is better equipped to lead his team to victory in the matchup with Panthers QB Kyle Allen.

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