Promethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Promethazine is well absorbed from the gastrointestinal tract. Some drugs may have another patient information leaflet. Avoid prolonged exposure to the sun. South Plainfield, NJ 07080 Promethazine is metabolized by the liver to a variety of compounds; the sulfoxides of promethazine and N-demethylpromethazine are the predominant metabolites appearing in the urine. Avoid sun, sunlamps, and tanning beds. 12.5 mg, white, bullet-shaped suppository wrapped in silver foil. Central Nervous System Oral solution: The oral solution should be measured with an accurate measuring device to decrease the risk of overdosage. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911. Webexplain the stability of the product at room temperature. 1992 Aug;46(4):223-31. doi: 10.18926/AMO/32623. Insert the suppository When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4 to 6 hours as needed. Remove the wrapper. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HCl SUPPOSITORIES HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. Box of 12 NDC 0713-0526-12 Promethazine: MedlinePlus Drug Information CAUTION SHOULD BE EXERCISED WHEN ADMINISTERING PROMETHAZINE HCL TO PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking promethazine. Anticholinergics Concomitant use of other agents with anticholinergic properties should be undertaken with caution. We comply with the HONcode standard for trustworthy health information. advice about side effects. Administration of 12.5 to 25 mg promethazine HCl by rectal suppository at bedtime will provide sedation in children. Files, Presentations Unable to load your collection due to an error, Unable to load your delegates due to an error. H-Phenothiazine, 10-ethanamine, WebTo insert a promethazine suppository, follow these steps: If the suppository feels soft, hold it under cold, running water for 1 minute. Updated Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. (See Webafter 24 hours of storage at room- temperature, when stored in a cool place (815 C), and when stored at room-temperature (1530 C). tell your doctor and pharmacist if you are allergic to promethazine, other phenothiazines (certain medications used to treat mental illness, nausea, vomiting, severe hiccups, and other conditions) or any other medications. J Pharm Pharmacol. Parenteral: Treatment: 12.5 to 25 mg IM, IV, orally, or rectally every 4 hours as needed However, many people have no side effects or only have minor side effects. Antiemetic therapy in postoperative patients. Nonteratogenic Effects Promethazine HCl 0713-0526-12 Promethegan Suppository Before Also tell your doctor and pharmacist if you have ever had an unusual or unexpected reaction when you took promethazine, another phenothiazine, or any other medication. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions. Alcohol can make the side effects of promethazine worse. Administered IV as an adjunct to anesthesia or analgesia with reduced amounts of meperidine of other narcotic analgesics in special surgical situations (e.g., repeated bronchoscopy, ophthalmic surgery, poor-risk patients), Therapy adjunctive to meperidine or other analgesics for control of postoperative pain. Use of Promethazine HCl Suppositories in patients with compromised respiratory function (e.g., COPD, sleep apnea) should be avoided. https://medlibrary.org/lib/rx/meds/promethegan-5/. Neuroleptic malignant syndrome (potentially fatal) has also been reported (See Patient Medication Information. 1978 Aug;67(8):1133-8. doi: 10.1002/jps.2600670828. Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Patient should remain supine for 17H WebWhen promethazine is used to relieve cold symptoms, it is usually taken every 4 to 6 hours as needed. suppository. AHFS 1 receptor blocking agent. and transmitted securely. Manufacturer Contact Information (Quality Control) InterMune, Inc. 888 PRECAUTIONS- Information for Patients and Drug Interactions). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Federal government websites often end in .gov or .mil. This possibility should be considered with Promethazine HCl Suppositories. Chem Pharm Bull (Tokyo). IV formulations should be diluted to a concentration of 25 mg/mL or less. 25 mg, white, bullet-shaped suppository wrapped in silver foil. Promethazine HCl, a phenothiazine derivative, is designated chemically as 10 It may cause very bad and sometimes deadly breathing problems. We comply with the HONcode standard for trustworthy health information. PMC Promethazine can interfere with the results of home pregnancy tests. promethazine Adults usually require 25 to 50 mg for nighttime, presurgical, or obstetrical sedation. WebPromethazine is an H1 receptor blocking agent. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. to you and the baby.

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